Cranos Williams

Bio

Research Interests: I am currently the director of the EnBiSys Research Laboratory. The EnBiSys Lab is a highly collaborative, multidisciplinary research laboratory, focused on the development of targeted computational and analytical solutions for modeling and controlling biological systems. The solutions we develop are used to build and strengthen the transition from large-scale high-throughput –omics data to highly connected kinetic models in the post-genomic era; models that can be used to attain the depth, understanding, and comprehension needed to manipulate and control biological systems for a defined purpose.

Specific interests in this field include:

– Nonlinear Systems Analysis
– System Identification
– Uncertainty Analysis
– Optimal Experimental Design
– Biological Signal and Data Processing

Patents: S. Chen, L. Ray, N. Cahill, M. Goodgame, and C. Williams, “Method of Image Registration using Mutual Information,” U.S. Patent 7,263,243, Aug. 28, 2007.

Area(s) of Expertise

Computational Intelligence, Machine Learning, Dynamic Systems Modeling, Multi-scale Modeling, Data Mining, Gene Regulatory Networks, Metabolic Pathway Modeling

Publications

• Spatiotemporal dynamics of NF-κB/Dorsal inhibitor IκBα/Cactus inDrosophilablastoderm embryos , (2024)
• The Black American experience: Answering the global challenge of broadening participation in STEM/agriculture , PLANT CELL (2024)
• Cellular clarity: a logistic regression approach to identify root epidermal regulators of iron deficiency response , BMC GENOMICS (2023)
• Compositionality, sparsity, spurious heterogeneity, and other data-driven challenges for machine learning algorithms within plant microbiome studies , CURRENT OPINION IN PLANT BIOLOGY (2023)
• FER and LecRK show haplotype-dependent cold-responsiveness and mediate freezing tolerance in Lotus japonicus , PLANT PHYSIOLOGY (2023)
• Multiplex CRISPR editing of wood for sustainable fiber production , SCIENCE (2023)
• Dynamics of BMP signaling in the earlyDrosophilaembryo , (2022)
• Identification of Transcription Factors Regulating SARS-CoV-2 Tropism Factor Expression by Inferring Cell-Type-Specific Transcriptional Regulatory Networks in Human Lungs , VIRUSES-BASEL (2022)
• POPEYE intercellular localization mediates cell-specific iron deficiency responses , PLANT PHYSIOLOGY (2022)
• Practical spectral photography II: snapshot spectral imaging using linear retarders and microgrid polarization cameras , OPTICS EXPRESS (2022)