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Think and Do The Extraordinary
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Rodolphe Barrangou

Todd R. Klaenhammer Distinguished Professor

Faculty

Schaub Food Science Building, Room 339B

919.513.1644

https://crispr.cals.ncsu.edu

Area(s) of Expertise

Our laboratory focuses on the biology and genetics of CRISPR-Cas immune systems in bacteria. Using microbiology, molecular biology and genomics approaches, we investigate the use of CRISPR-Cas systems for three types of applications:

  1. The exploitation of CRISPR spacer hypervariability for genotyping and phylogenetic studies of beneficial and pathogenic bacteria
  2. Leveraging CRISPR-mediated interference for building up phage resistance in probiotic strains and starter cultures used in food manufacturing
  3. Harnessing of Cas9-mediated, re-programmable dsDNA cleavage for genome editing in bacteria

These activities provide insights into the genetic and molecular processes that drive CRISPR-mediated adaptive immunity in bacteria and generate novel tools for the manipulation of industrially relevant organisms for food and biotechnological applications.

Teaching Activities

  • Introduction to Biopharmaceutical Sciences (BBS 201)
  • MR Supervised Research (FS 693)
  • Fermentation Microbiology (FS 725)
  • DR Supervised Research (FS 893)

Publications

View on Google Scholar

Education

M.B.A., Business Administration, University of Wisconsin – Madison (2011)
Ph.D., Functional Genomics, North Carolina State University (2004)
M.S., Food Science, North Carolina State University (2000)
M.S., Biological Engineering, University of Technology in Compiegne (2000)
B.S., Life Sciences, University of Paris V – Rene Descartes (1996)