Rodolphe Barrangou
Todd R. Klaenhammer Distinguished Professor
Schaub Food Science Building, Room 339B
Bio
Area(s) of Expertise
Our laboratory focuses on the biology and genetics of CRISPR-Cas immune systems in bacteria. Using microbiology, molecular biology and genomics approaches, we investigate the use of CRISPR-Cas systems for three types of applications:
- The exploitation of CRISPR spacer hypervariability for genotyping and phylogenetic studies of beneficial and pathogenic bacteria
- Leveraging CRISPR-mediated interference for building up phage resistance in probiotic strains and starter cultures used in food manufacturing
- Harnessing of Cas9-mediated, re-programmable dsDNA cleavage for genome editing in bacteria
These activities provide insights into the genetic and molecular processes that drive CRISPR-mediated adaptive immunity in bacteria and generate novel tools for the manipulation of industrially relevant organisms for food and biotechnological applications.
Teaching Activities
- Introduction to Biopharmaceutical Sciences (BBS 201)
- MR Supervised Research (FS 693)
- Fermentation Microbiology (FS 725)
- DR Supervised Research (FS 893)
Education
M.B.A. Business Administration University of Wisconsin - Madison 2011
Ph.D. Functional Genomics North Carolina State University 2004
M.S. Food Science North Carolina State University 2000
M.S. Biological Engineering University of Technology in Compiegne 2000
B.S. Life Sciences University of Paris V - Rene Descartes 1996