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Andrew Neilson

Associate Professor, Microbiome

Faculty

Plants for Human Health Institute (PHHI), 600 Laureate Way, Room 4229, Kannapolis, NC 28081

704.250.5495

Area(s) of Expertise

Dr. Neilson’s research focuses on the interactions between dietary phytochemicals (particularly flavonoids) and the gut microbiome, and how these interactions influence human health. Of specific interest are the bioactivities of microbial metabolites produced when the gut microbiome metabolizes unabsorbed dietary components. Specific health areas of interest include gut health and metabolic syndrome. Prior to joining PHHI, Dr. Neilson spent 7.5 years as a faculty member at Virginia Tech.

Professional Memberships

  • American Society for Nutrition
  • Phi Tau Sigma

Publications

  1. Jin Q, SF O’Keefe, AC Stewart, AP Neilson, YT Kim, H Huang, Techno-economic analysis of a grape pomace biorefinery: production of oil, polyphenols, and biochar. Food Bioprod Process 2021, In press. Manuscript Number: FBP-D-20-00989R1; DOI:10.1016/j.fbp.2021.02.002.
  2. Iglesias-Carres L*, MD Hughes*, CN Steele, MA Ponder, KP Davy, AP Neilson, Use of dietary phytochemicals for inhibition of trimethylamine N-oxide formation, J Nutr Biochem 2021, In press. Manuscript ID: JNB-D-20-00494R2. DOI: 10.1016/j.jnutbio.2021.108600. PMID: 33577949.
  3. Virdee M, N Saini, SC Kwan, AP Neilson, CD Kay, KK Helfrich, SM Mooney, SM Smith, An enriched biosignature of gut microbiota-dependent metabolites characterizes maternal plasma in a mouse model of fetal alcohol spectrum disorder, Sci Rep 2021; 11:248. DOI: 10.1038/s41598-020-80093-8. PMID: 33420159.
  4. Griffin LE*, SE Kohrt, A Rathore, CD Kay, MM Grabowska AP Neilson, Microbial metabolites of flavanols in urine are associated with enhanced anti-proliferative activity in bladder cancer cells in vitro, Nutr Cancer 2021; In press. DOI: 10.1080/01635581.2020.1869277. PMID: 33522303. Preprint (bioRciv) DOI: 10.1101/2020.09.22.308056.
  5. Bruno RS, AP Neilson, JD Lambert, N Moustaid-Moussa, Journal of Nutritional Biochemistry Special Issue: Polyphenols, Obesity, and Cardiometabolic Health, J Nutr Biochem 2021; 89:108565. DOI: 1016/j.jnutbio.2020.108565. PMID: 33321186.
  6. Griffin LE*, LA Essenmacher*, KC. Racine*, L Iglesias-Carres*, J. Tessem, SM Smith, AP Neilson, Diet-Induced obesity in genetically diverse collaborative cross mouse founder strains reveals diverse phenotype response and amelioration by quercetin treatment in 129S1/SvImJ, PWK/EiJ, CAST/PhJ and WSB/EiJ mice, J Nutr Biochem 2021; 87:108521. DOI: 10.1016/j.jnutbio.2020.108521. PMID: 33039581.
  7. Brunt VE, TJ LaRocca, AE Bazzoni, ZJ Sapinsley, J Miyamoto-Ditmon, R. Gioscia-Ryan, AP Neilson, CD Link, DR Seals, The gut microbiome-derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging, GeroScience 2020; In press. Manuscript ID: JAAA-D-20-00180R2. DOI: DOI: 10.1007/s11357-020-00257-2. PMID: 32862276.
  8. Li M, LE Griffin*, SA Corbin, AP. Neilson, MG Ferruzzi, Modulating phenolic bioaccessibility and glycemic response of starch-based food models by physical complexation between starch and phenolic acid, J Agric Food Chem 2020, 68:13257–13266. DOI: 10.1021/acs.jafc.0c01387. PMID: 32689794.
  9. Brunt VE, RA Gioscia-Ryan, AG. Casso, NS VanDongen, BP Ziemba, ZJ Sapinsley, JJ Richey, MC Zigler, AP Neilson, KP Davy, DR Seals, Trimethylamine N-oxide promotes age-related vascular oxidative stress and endothelial dysfunction in mice and healthy humans, Hypertension 2020, 76:101–112. DOI: 10.1161/HYPERTENSIONAHA.120.14759. PMID: 32520619.
  10. Jin Q, Z Wang, Y Feng, YT Kim, AC Stewart, SF O’Keefe, AP Neilson, Z He, H Huang, Grape pomace and its secondary waste management: biochar production for a broad range of lead (Pb) removal from water. Environmental Research 2020, 186:109442. DOI: 10.1016/j.envres.2020.109442. PMID: 32302873.
  11. Baugh ME, SM Bowser, RP McMillan, LA Essenmacher*, BM Davy, MW Hulver, AP Neilson, KP Davy, Postprandial skeletal muscle metabolism following a high fat diet in sedentary and endurance trained males. J Appl Physiol 2020, 128:872-883. DOI: 10.1152/japplphysiol.00576.2019. PMID: 32163335.
  12. Wang Y, A Wang, H Alkhalidy, J Luo, E Moomaw, AP. Neilson, K Zhou, D Liu, Flavone hispidulin stimulates glucagon-like peptide-1 secretion and ameliorates hyperglycemia in streptozotocin-induced diabetic mice, Mol Nutr Food Res 2020; 64:1900978. DOI: 10.1002/mnfr.201900978. PMID: 31967385.
  13. Jin Q, J O’Hair, AC Stewart, SF O’Keefe, AP Neilson, Y Kim, M McGuire, A Lee, G Wilder, H Huang, Compositional characterization of different industrial white and red grape pomaces in Virginia and the potential valorization of the major components, Foods 2019; 8:667. DOI: 10.3390/foods8120667. PMID 31835812.
  14. Racine KC*, BD Wiersema LE Griffin*, LA Essenmacher*, AH Lee, H Hopfer, JD Lambert, AC Stewart, AP Neilson, Flavanol polymerization is a superior predictor of α-glucosidase inhibitory activity compared to flavanol or total polyphenol concentrations in cocoas prepared by variations in controlled fermentation and roasting of the same raw cocoa beans, Antioxidants 2019; 8:635. DOI: 10.3390/antiox8120635. PMID 31835748.
  15. Bowser SM, RP McMillan, NE Boutagy, MD Tarpey, AT Smithson*, KL Osterberg, MI Frisard, AP Neilson, BM Davy, KP Davy, MW Hulver, Serum endotoxin, gut permeability and skeletal muscle metabolic adaptations following a short-term high fat diet in humans, Metabolism 2020; 103:154041. DOI: 10.1016/j.metabol.2019.154041. PMID: 31785256.
  16. Griffin LE*, C Diako, LE Miller, AP Neilson, CF Ross, AC Stewart, Preference for and sensitivity to flavanol mean degree of polymerization in model wines is correlated with body composition. Appetite 2020; 144:104442. DOI: 10.1016/j.appet.2019.104442. PMID: 31494153.
  17. Yu D, Y Sun, W Wang, SF O’Keefe, AP Neilson, H Feng, Z Wang, H Huang. 2019. Recovery of protein hydrolysates from brewer’s spent grain using enzyme and ultrasonication. Int J Food Sci Tech 2020; 55, 357–368. DOI: 10.1111/ijfs.14314.
  18. Ma S, C Kim, LE Griffin*, AP. Neilson, GM Peck, SF O’Keefe, AC Stewart, Comparison of common analytical methods for the quantification of total polyphenols and flavanols in fruit juices and ciders, J Food Sci 2019; 84:2147-2158. DOI: 10.1111/1750-3841.14713. PMID: 31313833.
  19. Farzad R, DD Kuhn, SA Smith, SF O’Keefe, NVC Ralston, AP Neilson, DM Gatlin, Trace minerals in tilapia fillets: status in the united states marketplace and selenium supplementation strategy for improving consumer’s health, PLoS ONE 2019; 14(6): e0217043. DOI: 1371/journal.pone.0217043. PMID: 31170189.
  20. Griffin LE*, Z Djuric, CJ Angiletta, C Mitchell, ME Baugh, KP Davy, AP Neilson, A Mediterranean diet does not alter plasma trimethylamine N-oxide concentrations in healthy adults at risk for colon cancer, Food Funct 2019; 10: 2138-2147. DOI: 10.1039/C9FO00333A. PMID: 30938383.
  21. Griffin LE*, DW Fausnacht, JL Tuzo, AK Addington, KC. Racine*, H Zhang, MD Hughes*, KM England, RS Bruno, SF O’Keefe, AP Neilson, AC Stewart, Flavanol supplementation protects against obesity-associated increases in systemic IL-6 levels without inhibiting body mass gain in mice fed a high-fat diet, Nutr Res 2019; 66:32-47. DOI: 10.1016/j.nutres.2019.03.011. PMID: 31051320.
  22. Racine KC*, AH Lee, B Wiersema, H Huang, JD Lambert, AC Stewart, AP Neilson, Development and characterization of a pilot-scale model cocoa fermentation system suitable for studying the impact of fermentation on phenolic compounds and quality of cocoa, Foods 2019; 8:102. DOI: 10.3390/foods8030102.PMID: 30893898.
  23. Racine KC*, AH Lee, AC Stewart, KW Blakeslee, AP Neilson, Development of a rapid ultraperformance hydrophilic interaction liquid chromatography tandem mass spectrometry method for procyanidins with enhanced ionization efficiency, J Chromatogr A 2019; 1594:54-64. DOI: 0.1016/j.chroma.2019.02.007. PMID: 30857739.
  24. Brunt VE, RA Gioscia-Ryan, JJ Richey, MC Zigler, LM Cuevas, A Gonzalez, Y Vázquez-Baeza, ML Battson, AT Smithson*, AD Gilley*, G Ackermann, AP Neilson, T Weir, KP Davy, R Knight, DR Seals, Suppression of the gut microbiome ameliorates age-related arterial dysfunction and oxidative stress in mice, J Physiol 2019; 597:2361-2378. DOI: 10.1113/JP277336. PMID: 30714619.
  25. Jin Q, AP Neilson, AC Stewart, SF O’Keefe, YT Kim, M McGuire, G Wilder, H Huang, An integrated approach for the valorization of red grape pomace: production of oil, polyphenols, and acetone-butanol-ethanol, ACS Sustain Chem Eng 2018; 6:16279–16286. DOI:1021/acssuschemeng.8b03136.
  26. Ewing BL, GM Peck, S Ma, AP Neilson, AC Stewart, Management of apple maturity and post-harvest storage conditions to increase polyphenols in cider, Sci Hortic-Amsterdam 2019; 245: 511–519. DOI: 10.1007/s00217-018-3171-8.
  27. Mitchell M, BM Davy, MW Hulver, AP Neilson, BJ Bennett, KP Davy, Does exercise alter gut microbial composition? A systematic review, Med Sci Sport Exer 2019; 51:160–167. DOI: 10.1249/MSS.0000000000001760. PMID: 30157109.
  28. Lee AH, SF O’Keefe, AP Neilson, JA Ogejo, H Huang, MA Ponder, HSS Chu, Q Jin, G Pilot, AC Stewart, A laboratory-scale model cocoa fermentation using dried, unfermented beans and artificial pulp can simulate the microbial and chemical changes of on-farm cocoa fermentation, Eur Food Res Technol 2018; 245: 511-519. DOI: 10.1007/s00217-018-3171-8.
  29. Angiletta CJ, LE Griffin*, CN Steele, DJ Baer, JA Novotny, KP Davy, AP Neilson, Impact of short-term flavanol supplementation on fasting plasma trimethylamine N-oxide concentrations in obese adults, Food Funct 2018;9:5350-5361. DOI: 10.1039/C8FO00962G. PMID: 30264073.
  30. Bitner BF, JD Ray, KB Kener, JA Herring, JA Tueller, DK Johnson, CM Tellez Freitas, DW Fausnacht, ME Allen, AH Thomson, KS Weber, RP McMillan, MW Hulver, DA Brown, JS Tessem, AP Neilson, Common gut microbial metabolites of dietary flavonoids exert potent anti-diabetes activities in β-cell and skeletal muscle cell models, J Nutr Biochem 2018; 62:95-107. DOI:10.1016/j.jnutbio.2018.09.004. PMID: 30286378.
  31. Ma S, AP Neilson, J Lahne, GM Peck, SF O’Keefe, EK Hurley, A Sandbrook, AC Stewart, Juice clarification with pectinase reduces yeast assimilable nitrogen in apple juice without affecting the polyphenol composition in cider, J Food Sci 2018; 83: 2772-2781. DOI: 10.1111/1750-3841.14367. PMID:  30347443.
  32. Ma S, AP Neilson, J Lahne, GM Peck, SF O’Keefe, AC Stewart, Free amino acid composition of apple juices with potential for cidermaking as determined by UPLC-PDA, J I Brewing 2018; 124: 467–476. DOI: 10.1002/jib.519.
  33. KKHY Ho, Haufe TC*, MG Ferruzzi, AP Neilson, Production and polyphenolic composition of tea, Nutr Today2018; 53:268-278. DOI: 10.1097/NT.0000000000000304.
  34. TC Haufe*, KKHY Ho, MG Ferruzzi, AP Neilson, Potential health effects of tea, Nutr Today 2018; 53:213–228. DOI: 10.1097/NT.0000000000000294.
  35. Wu J, KM Goodrich*, JD Eifert, ML Jahncke, SF O’Keefe, GE Welbaum, AP Neilson, Inhibiting food-borne pathogen Vibrio parahaemolyticus and Listeria monocytogenes using extracts from selected traditional medicine Chinese gallnut (Galla chinensis), pomegranate (Punica granatum L.) peel, Baikal skullcap (Scutellaria baicalensis) root and forsythia fruit (Forsythia suspensa), Open Agric 2018; 3:163-170. DOI: 10.1515/opag-2018-0017.
  36. Baugh ME, CN Steele, CJ Angiletta, CM Mitchell, AP Neilson, BM Davy, MW Hulver, KP Davy, Inulin supplementation does not reduce plasma trimethylamine N-oxide concentrations in individuals at risk for type 2 diabetes, Nutrients 2018; 10:793. DOI: 10.3390/nu10060793. PMID: 29925775.
  37. Stoneham TR, DD Kuhn, DP Taylor, AP Neilson, SA Smith, DM Gatlin, HSS Chu, SF O’Keefe, Production of omega-3 enriched tilapia through the dietary use of algae meal or fish oil: improved nutrient value of fillet and offal, PLoS ONE 2018; 13(4):e0194241. DOI: 10.1371/journal.pone.0194241. PMID: 29641539.
  38. Winslow CJ*, BLB Nichols, DC Novo, LI Mosquera-Giraldo, LS Taylor, KJ Edgar, AP Neilson, Cellulose-based amorphous solid dispersions enhance rifapentine delivery characteristics in vitro, Carb Pol 2018; 182:149-158. DOI: 10.1016/j.carbpol.2017.11.024. PMID: 29279109.
  39. Moore LB, SV Liu, TM Halliday, AP Neilson, V Hedrick, BM Davy, Urinary excretion of sodium, nitrogen, and sugar are valid biomarkers of dietary sodium, protein, and sugar intake in non-obese adolescents, J Nutr 2017; 147:2364-2373 DOI: 10.3945/jn.117.256875. PMID: 28931586.
  40. Griffin LE*, KA Witrick*, C Klotz, MR Dorenkott*, KM Goodrich*, G Fundaro, RP McMillan, MW Hulver, MA Ponder, AP Neilson, Alterations to metabolically active bacteria in the mucosa of the small intestine predict anti-obesity and anti-diabetic activities of grape seed extract in mice, Food Funct 2017; 8:3510-3522. DOI: 10.1039/C7FO01236E. PMID: 28875188.
  41. Rowley IV TJ, BF Bitner, JD Ray, DR Lathen, AT Smithson*, BW Dallon, CJ Plowman, BT Bikman, JM Hansen, MR Dorenkott*, KM Goodrich*, L Ye, SF O’Keefe, AP Neilson, JS Tessem, Monomeric cocoa catechins enhance β-cell function by increasing mitochondrial respiration, J Nutr Biochem 2017; 49:30-41. DOI: 10.1016/j.jnutbio.2017.07.015. PMID: 28863367.
  42. Levy J, RR Boyer, AP Neilson, SF O’Keefe, HSS Chu, RC Williams, MR Dorenkott*, KM Goodrich, Evaluation of Peanut Skin and Grape Seed Extract to Inhibit Growth of Foodborne Pathogens, Food Sci Nutr, 2017; 5: 1130–1138. DOI: 10.1002/fsn3.503. PMID: 29188040.
  43. Smiljanec K, C Mitchell, O Privitera, K Davy, A Neilson, B Davy, Pre-meal inulin consumption does not affect acute energy intake in overweight and obese middle-aged and older adults: A randomized controlled crossover pilot trial, Nutr Health 2017; 23:75-81. DOI: 10.1177/0260106017699632. PMID: 28413905.
  44. Bacon K, RR Boyer, C Denbow, SF O’Keefe, AP Neilson, RC Williams, Antibacterial Activity of Jalapeño pepper (Capsicum annuum annuum) extract fractions against select foodborne pathogens, Food Sci Nutr2017; 5:730–738. DOI: 10.1002/fsn3.453. PMID:  28572963.
  45. Ryan CM*, W Khoo, AC Stewart, SF O’Keefe, JD Lambert, AP Neilson, Flavanol concentrations do not predict dipeptidyl peptidase-IV inhibitory activities of four cocoas with different processing histories, Food Funct 2017; 8:746-756. DOI: 10.1039/C6FO01730D. PMID: 28106217.
  46. Bowser SM, WT Moore, RP McMillan, MR Dorenkott*, KM Goodrich*, L Ye, SF O’Keefe, MW Hulver, AP Neilson, High molecular weight cocoa procyanidins possess enhanced insulin-enhancing and insulin mimetic activities in human primary skeletal muscle cells compared to smaller procyanidins, J Nutr Biochem 2016; 39:48-58. DOI: 10.1016/j.jnutbio.2016.10.001. PMID: 27816760.
  47. Gilley AD*, HC Arca, BLB Nichols, LI Mosquera-Giraldo, LS Taylor, KJ Edgar, AP Neilson, Novel cellulose-based amorphous solid dispersions enhance quercetin solution concentrations in vitro, Carbohyd Polym 2016; 157:86–93. DOI: 10.1016/j.carbpol.2016.09.067. PMID: 27988001.
  48. SL Glisan, CM Ryan*, AP Neilson, JD Lambert, Cranberry extract attenuates hepatic inflammation in high fat-fed obese mice. J Nutr Biochem 2016; 37:60-66. DOI: 10.1016/j.jnutbio.2016.07.009. PMID: 27619543.
  49. Bacon K, RR Boyer, C Denbow, SF O’Keefe, AP Neilson, RC Williams, Evaluation of different solvents to extract antibacterial compounds from jalapeño peppers, Food Sci Nutr 2017; 5:497–503. DOI: 10.1002/fsn3.423. PMID: 28572934.
  50. Haufe TC*, AD Gilley*, KM Goodrich*, CM Ryan*, AT Smithson*, MW Hulver, D Liu, AP Neilson,.Grape powder attenuates the negative effects of GLP-1 receptor antagonism by exendin-3 (9-39) in a normoglycemic mouse model. Food Funct 2016; 7:2692 – 2705. DOI: 10.1039/C6FO00122J. PMID: 27189193.
  51. Ryan CM*, W Khoo, L Ye, SF O’Keefe, JD Lambert, AP Neilson, Loss of native flavanols during fermentation and roasting does not necessarily reduce digestive enzyme inhibiting bioactivities of cocoa, J Agric Food Chem 2016; 64:3616-3625. DOI: 10.1021/acs.jafc.6b01725. PMID: 27094258.
  52. Ye L, AP Neilson, P Sarnoski, WK Ray, SE Duncan, RR Boyer, SF O’Keefe.  Comparison of A-type procyanidins in cranberry and peanut skin extracts using matrix assisted laser desorption ionization-time of flight mass spectrometry. J Mol Genet Med 2016; 10:209. DOI: 10.4172/1747-0862.1000209.
  53. Baek N, AP Neilson, WN Eigel, SF O’Keefe, Antioxidant properties of a dihydromyricetin-rich extract from vine tea (Ampelopsis grossedentata) in menhaden oil. Res Rev J Bot Sci 2016; 4:3. PDF Link.
  54. Strat KM*, TJ Rowley IV, AT Smithson*, JS Tessem, MW Hulver, D Liu, BM Davy, KP Davy, AP Neilson, Mechanisms by which cocoa flavanols improve metabolic syndrome and related disorders, J Nutr Biochem2016; 35:1-21. DOI: 10.1016/j.jnutbio.2015.12.008. PMID: 27560446.
  55. Neilson AP, BW Bolling, SF O’Keefe, High molecular weight procyanidins in foods: Overcoming analytical challenges in pursuit of novel dietary bioactive components, Annu Rev Food Sci Technol 2016; 7:3.1–3.22. DOI: 1146/annurev-food-022814-015604.
  56. Boutagy NE, AP Neilson, KL Osterberg, AT Smithson*, TR Englund, BM Davy, MW Hulver, KP Davy, Probiotic supplementation and trimethylamine-N-oxide production following high fat feeding, Obesity 2015; 23:2357–2363. DOI: 10.1002/oby.21212. PMID: 26465927.
  57. Mitchell CM, BM Davy, TM Halliday, MW Hulver, AP Neilson, MA Ponder, KP Davy, The effect of prebiotic supplementation with inulin on the gut microbiome and cardio-metabolic health: Rationale, design, and methods of a controlled feeding efficacy trial in adults at risk for type 2 diabetes, Contemp Clin Trials 2015; 45:328-337. DOI:10.1016/j.cct.2015.10.012. PMID: 26520413
  58. Boutagy NE, AP Neilson, KL Osterberg, AT Smithson*, TR Englund, BM Davy, MW Hulver, KP Davy, Short-term high-fat diet increases postprandial trimethylamine-N-oxide in humans, Nutr Res 2015; 35:858-864. DOI: 10.1016/j.nutres.2015.07.002. PMID: 26265295.
  59. Goodrich KM*, AT Smithson*, AK Ickes*, AP Neilson, Pan-colonic pharmacokinetics of catechin and procyanidins in male Sprague Dawley rats, J Nutr Biochem 2015; 26:1007-1014. DOI: 10.1016/j.j.nut.bio.2015.04.008. PMID: 26026837.
  60. Djuric Z, DK Turgeon, J Ren, AP Neilson, M Plegue, IG Waters, A Chan, LM Askew, RT Muffin 4th, DE Brenner, Effects of a Mediterranean diet intervention on anti- and pro-inflammatory eicosanoids, epithelial proliferation, and nuclear morphology in biopsies of normal colon tissue, Nutr Cancer 2015; 67:721-729. DOI: 10.1080/01635581.2015.1029637. PMID: 25869112.
  61. Stanley TH, AT Smithson*, AP Neilson, RC Anantheswaran, JD Lambert, Analysis of cocoa proanthocyanidins using reversed phase high-performance liquid chromatography and electrochemical detection: application to studies on the effect of alkaline processing, J Agric Food Chem 2015; 63:5970-5975. DOI: 1021/acs.jafc.5b02661. PMID: 26042917.
  62. Bitzer ZT, SL Glisan, MR Dorenkott*, KM Goodrich*, L Ye, SF O’Keefe, JD Lambert, AP Neilson, Cocoa procyanidins with different degrees of polymerization possess distinct activities in models of colonic inflammation, J Nutr Biochem 2015; 26:827-831. DOI: 10.1016/j.jnutbio.2015.02.007. PMID: 25869594. PMID: 25581427.
  63. Bianchi LM, SE Duncan, JB Webster, AP Neilson, SF O’Keefe, Contribution of chlorophyll to photooxidation of soybean oil at specific visible wavelengths of light, J Food Sci 2015; 80:C252-C261. DOI: 10.1111/1750-3841.12751.
  64. Goodrich KM*, MR Dorenkott*, L Ye, SF O’Keefe, MW Hulver, AP Neilson, Dietary supplementation with cocoa flavanols does not alter colonic profiles of native flavanols and their microbial metabolites established during habitual dietary exposure in C57BL/6J mice, J Agric Food Chem 2014; 62:11190–11199. DOI: 10.1021/jf503838q. PMID: 25336378.
  65. Thompson-Witrick KA*, KM Goodrich*, AP Neilson, EK Hurley, GM Peck, AC Stewart, Characterization of the phenolic composition of cider, processing, and dessert apples grown in Virginia, J Agric Food Chem 2014; 62:10181-10191. DOI: 10.1021/jf503379t. PMID: 25228269.
  66. Laourdakis CD, EF Merino, AP Neilson, MB Cassera, Comprehensive quantitative analysis of purines and pyrimidines in the human malaria parasite using ion-pairing ultra-performance liquid chromatography-mass spectrometry, J Chromatogr B 2014; 967:127-133. DOI: 10.1016/j.jchromb.2014.07.012. PMID: 25089957.
  67. Dorenkott MR*, LE Griffin*, KM Goodrich*, KA Thompson-Witrick*, G Fundaro, L Ye, JR Stevens, M Ali, SF O’Keefe, MW Hulver, AP Neilson, Oligomeric cocoa procyanidins possess enhanced bioactivity compared to monomeric and polymeric cocoa procyanidins for preventing the development of obesity, insulin resistance, and impaired glucose tolerance during high-fat feeding, J Agric Food Chem 2014; 62:2216-2227. DOI: 10.1021/jf500333y. PMID: 24559282.
  68. Goodrich KM*, AP Neilson, Simultaneous UPLC-MS/MS analysis of native catechins and procyanidins and their microbial metabolites in intestinal contents and tissues of Wistar-Furth inbred rats, J Chromatogr B 2014; 958:63-74. DOI: 10.1016/j.jchromb.2014.03.011. PMID: 24704909.
  69. Goodrich KM*, G Fundaro, LE Griffin*, A Grant, MW Hulver, MA Ponder, AP Neilson, Chronic administration of dietary grape seed extract increases colonic expression of gut tight junction protein occludin and reduces fecal calprotectin: a secondary analysis of healthy Wistar Furth rats, Nutr Res 2012; 32:787-794. DOI: 10.1016/j.nutres.2012.09.004. PMID: 23146776.
  70. Neilson AP, J Ren, S Reuven, C Lager, YH Hong, A Sen, WL Smith, DE Brenner, Z Djuric, Effect of cyclooxygenase genotype and dietary fish oil on colonic eicosanoids in mice, J Nutr Biochem 2012; 23:966-976. DOI: 10.1016/j.jnutbio.2011.05.003. PMID: 21937210.
  71. Neilson AP, J Ren, YH Hong, A Sen, WL Smith, DE Brenner, Z Djuric, Effect of fish oil on levels of R- and S-enantiomers of 5-, 12- and 15-hydroxyeicosatetraenoic acids in mouse colonic mucosa, Nutr Cancer 2011; 64:163-172. DOI: 10.1080/01635581.2012.630168. PMID: 22149144
  72. Neilson AP, Z Djuric, S Land, I Kato, Plasma levels of resistin-like molecule beta in humans, Cancer Epidemiol2011; 35:485-489. DOI: 10.1016/j.canep.2010.10.007. PMID: 21094111.
  73. Neilson AP, MG Ferruzzi, Influence of formulation and processing on absorption and metabolism of flavan-3-ols from food, Annu Rev Food Sci Technol, 2011; 2:125-151. DOI: 10.1146/annurev-food-022510-133725. PMID: 22129378.
  74. Gutierrez-Orozco F, BR Stephens, AP Neilson, RJ Green, MG Ferruzzi, JA Bomser, Green and black tea inhibit cytokine-induced IL-8 production and secretion in AGS gastric cancer cells via inhibition of NF-κB activity, Planta Med 2010; 76: 1659-1665. DOI: 10.1055/s-0030-1249975. PMID: 20506079.
  75. Neilson AP, TN Sapper, E Janle, R Rudolf, NV Matusheski, MG Ferruzzi, Chocolate matrix factors modulate pharmacokinetic behavior of cocoa flavan-3-ol phase-II metabolites following oral consumption by Sprague-Dawley rats, J Agric Food Chem 2010; 58: 6685–6691. DOI: 10.1021/jf1005353. PMID: 20446738.
  76. Neilson AP, BJ Song, TN Sapper, JA Bomser, MG Ferruzzi, Tea catechin auto-oxidation dimers are accumulated and retained by Caco-2 human intestinal cells, Nutr Res 2010; 30:327-340. DOI: 10.1016/j.nutres.2010.05.006. PMID: 20579525.
  77. Neilson AP, JC George, EM Janle, RD Mattes, R Rudolph, NV Matusheski, MG Ferruzzi, Influence of chocolate matrix composition on cocoa flavan-3-ol bioaccessibility in vitro and bioavailability in humans, J Agric Food Chem 2009; 57: 9418–9426. DOI: 10.1021/jf902919k. PMID: 19780539.
  78. Neilson AP, AS Hopf, BR Cooper, MA Pereira, JA Bomser, MG Ferruzzi, Catechin degradation with concurrent formation of homo- and heterocatechin dimers during in vitro digestion, J Agric Food Chem 2007; 55:8941. DOI: 10.1021/jf071645m. PMID: 17924707.
  79. Neilson AP, RJ Green, KV Wood, MG Ferruzzi, High-throughput analysis of catechins and theaflavins by high performance liquid chromatography with diode array detection, J Chromatogr A 2006; 1132:132. DOI: 10.1016/j.chroma.2006.07.059. PMID: 16919286.
  80. Neilson AP, HF Pahulu, LV Ogden, OA Pike, Sensory and nutritional quality of dehydrated potato flakes in long-term storage, J Food Sci 2006; 71:S461. DOI: 10.1111/j.1750-3841.2006.00084.x.

*undergraduate student, graduate student or postdoc in Dr. Neilson’s lab group
Corresponding author listed in bold.

Publications

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Education

Ph.D., Food Science, Purdue University (2009)
B.S., Food Science, Brigham Young University (2005)