Josh Pierce

Bio

Josh is employing synthetic chemistry to tackle problems in chemical biology and drug discovery. Through the development of novel reactions he aims to synthesize complex natural products and use targeted modifications to lend insight into their biological mechanism of action. Ultimately, these efforts will uncover novel drug lead compounds for further development. Josh was named the Director of the NC State Integrative Sciences Initiative in 2022.

Publications

• Expanded library of novel 2,3-pyrrolidinedione analogues exhibit anti-biofilm activity , BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2024)
• Total Synthesis and Microbiological Evaluation of Leopolic Acid A and Analogues , ACS BIO & MED CHEM AU (2024)
• 3-Component Approach to 1,5-Dihydro-2H-pyrrol-2-one Heterocycles , ORGANIC SYNTHESES (2023)
• Photoredox Catalyzed C(sp³)-C(sp³) Coupling of α-Bromoesters and Triethylamine , JOURNAL OF ORGANIC CHEMISTRY (2023)
• Using Stem Mini-Organs to Find New Cures , (2023)
• Chemistry Drives Solutions to Our Planet’s Largest Problems: COVID-19 and Beyond , (2022)
• Restoring Carboxylates on Highly Modified Alginates Improves Gelation, Tissue Retention and Systemic Capture , ACTA BIOMATERIALIA (2022)
• Synthesis provides insight into a traditional medicine , NATURE (2022)
• Tissue-reactive drugs enable materials-free local depots , JOURNAL OF CONTROLLED RELEASE (2022)
• Total Synthesis of Bipolamine I , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)