Tekan Rana (MHS Seminar). Muscadines (Vitis rotundifolia) are the native grape to the Southeast, traditionally used as a fresh market snack and for wine production. Before prohibition, North Carolina (NC) was the largest wine-producing state in the US, mostly shouldered by a large commercial muscadine industry. Today, the largest winery at the East Coast is Duplin Winery, which produces more than 450,000 cases of muscadine wine every year.