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Seminar: Tim Kelliher – Disrupting Crop Breeding with Genome Editing and Haploid Induction

November 18, 2019 | 3:00 pm - 4:00 pm EST

Dr. Tim Kelliher
Principal Scientist, Reproduction Biology, Syngenta

Genome editing using CRISPR-Cas9 works efficiently in plant cells, but delivery of genome editing machinery into the vast majority of crop varieties is not possible using established methods. We co-opted the aberrant reproductive process of haploid induction (HI) to induce edits in nascent seeds of diverse monocot and dicot species. Our method, named “HI-Edit”, enables direct genomic modification of commercial crop varieties. HI-edit was tested in field and sweet corn using a native haploid inducer line, and extended to dicots using an engineered CENH3 HI system. We also recovered edited wheat embryos using Cas9 delivered by maize pollen. Our data indicate that a transient hybrid state precedes uniparental chromosome elimination in maize HI. Edited haploid plants lack both the haploid inducer parental DNA and the editing machinery. Therefore, edited plants could be used in trait testing and directly integrated into commercial variety development.

Participate via ZOOM:

Dr. Tim Kelliher is the Science Fellow and Team Leader of the Reproductive Biology Team in the Performance Traits Seeds Research Group at Syngenta. If you would like to meet with him on November 18 in your office, please let me ( know what your availability are.
Tim is an expert in plant reproductive biology in both the fundamental biology and its applications to plant breeding, seed reproduction and yield improvement. His recent publications can be seen here:


November 18, 2019
3:00 pm - 4:00 pm EST
Event Categories:
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121 Kilgore Hall
2721 Founders Drive
Raleigh, NC 27606 United States
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Rachel McLaughlin
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