Giuseppe Valacchi

Bio

Giuseppe Valacchi is a David H. Murdock Distinguished Professor and Professor of Regenerative Medicine at North Carolina State University. In addition, he is an International Scholar at Kyung Hee University, Seoul, South Korea. He obtained his BS (Physiology) with Laude, his M.S. in Physiopathology and his Ph.D. in Cellular Physiology and Neuroimmuno-Physiology from the University of Siena, Italy. 

His research has been focused in understanding the cellular and molecular redox mechanisms that define the tissues physio-pathological responses to endogenous and exogenous factors (Exposome)  with special focus on target tissues such as skin and respiratory tract.

He is the author of over 300 peer reviewed international manuscripts, 20 book chapters, and 4 books. He has been a member of the Society of Free Radical Research -Europe (SFRR-Europe) Council from 2017 to 2021. From 2023 he is the SFRR-Europe President Elect. He has won several awards, among them the Entelligence Award from Actelion, the Exposome Award, the University of Ferrara Bronze Medal (2020 from the Rector of Ferrara, Prof. Zauli). In 2018 he was awarded with the “Doctorate Honoris Causa” in Biochemistry and Pharmacy from the University of Buenos Aires.  In 2019 he was the recipient of the Clinical Research award from the SFRR-E and in 2021, he was awarded in Rome, as “Paladin of Health” from the Italian Ministry of Public Health and Education. In 2022, he was nominated and awarded with the title of “Faculty Scholar” at North Carolina State University, a title that recognizes and rewards emerging academic leaders who demonstrate significant achievement. From 2022 he is a David H. Murdock Distinguished Professor in Regenerative Medicine at NCSU.

He is Editor for Archives in Biochemistry and Biophysics and for Redox Experimental Medicine; Associate Editor for Oxidative Medicine and Cellular Longevity, Mediators of Inflammation, Biomed (dermatology); member of the Editorial board of several international journals including, Free Radicals in Biology and Medicine, Antioxidants, Biofactors, Genes and Nutrition.

H index: 69 (scholar), 56 (Scopus)

Area(s) of Expertise

Redox Biology
Focus Area: Rare diseases such as Autism and Rett Syndrome; exposome effect on target tissues, skin, lung and GI tract

Publications

• Defective PI3K/Akt–FoxO3a–mediated stress adaptation in Rett syndrome , Free Radical Biology and Medicine (2026)
• Design and Characterization of a Transethosome‐Based Gel for Cutaneous Administration of Genistein , Journal of Nanotechnology (2026)
• Exogenous myrosinase from mustard seed increases bioavailability of sulforaphane from a glucoraphanin-rich broccoli seed extract in a randomized clinical study , Scientific Reports (2026)
• FOXO3 involvement in neurological OxInflammation , Redox Experimental Medicine (2026)
• MAM proteomics identifies progressive ER–mitochondria signaling disfunction in Rett syndrome , Free Radical Biology and Medicine (2026)
• MeCP2 deficiency promotes mitochondrial alterations and inflammaging-related dysfunctions in ovaries: potential implications for neurodevelopmental disorders , Free Radical Biology and Medicine (2026)
• Mitochondrial dysfunction and ox inflammatory signatures across Rett Syndrome progression: integrating in vitro and ex vivo evidence , Free Radical Biology and Medicine (2026)
• Oxysterol-induced oxidative disruption of skin junction integrity , Free Radical Biology and Medicine (2026)
• Targeting NF-κB/Nrf2 crosstalk restores redox–inflammatory signaling in Rett Syndrome , Free Radical Biology and Medicine (2026)
• Therapeutic Potential of Ozonized Glycerin in Skin Inflammation and Repair , Cosmetics (2026)

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