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Kerim Eroglu

Assistant Professor

Plants for Human Health Institute, 600 Laureate Way, Room 3204, Kannapolis, NC

704.250.5455

Research Program Overview

The Eroglu Lab uses transdisciplinary approaches to unravel how major dietary carotenoids affect our genes and how our genetic makeup influence response to carotenoid status. We exploit multiple disciplines including genome stability (DNA damage at the molecular level), changes in our epigenome (DNA methylation), RNA expression (transcriptomics), protein expression (proteomics), and metabolic profiling (metabolomics).

Projects in the Eroglu Lab:

Project 1: Determine bioavailability and cellular uptake of major dietary carotenoids and investigate their effects on subclinical inflammation

Project 2: Establish the effects of oxidative stress on carotenoid and retinoid metabolism using in vitro and animal models

Project 3: Elucidate the molecular mechanisms behind the protective and chemoprotective properties of carotenoids

Project 4: Develop biomarkers of carotenoid status linked to carotenoid metabolism and function

Project 5: Provide sustainable solutions for major public health problems such as reducing the burden of vitamin A deficiency

Research interests in Biochemistry:

-Carotenoid chemistry and metabolism
-Enzymology
-Epigenetics
-Lipid metabolism
-Metabolomics
-Metagenomics
-Proteomics
-Retinoid metabolism

Research interests in Nutrition:

-Biomarkers
-Biofortification of crops
-Intestinal absorption of carotenoids
-Nutrient and Gene Interactions
-Nutrigenomics
-Vitamin A deficiency
-Vitamin A metabolism

 

Publications

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Education

B.S. , Molecular Biology and Genetics, Istanbul Halic University (2005)
Ph.D., Ohio State Biochemistry Interdisciplinary Program, Ohio State University (2012)
Kagome Research Scholar, Chemoprotection Center, Johns Hopkins University School of Medicine (2016)
Nutritional Biochemist, Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health (2018)