Flora Meilleur
Professor
Joint Faculty, Neutron Scattering Division, Oak Ridge National Laboratory
Molecular and Structural Biochemistry
Oak Ridge National Laboratory
Enzyme Structure and Function
Polk Hall 141
[email protected] WebsiteBio
Research Interests
Research in the Meilleur lab focuses on mapping intra- and intermolecular interactions that govern enzyme function within the microenvironment of the catalytic site. Knowledge of local electrostatics, hydrogen-bonding networks and protonation states of titratable catalytic residues is essential for proper thermodynamic modeling and for predicting binding interactions in molecular recognition and catalysis.We use primarily a combination of X-ray and neutron diffraction and scattering to probe enzyme structure, dynamics and function.
Education
M.S. Structural Biology Université Joseph Fourier, Grenoble 2000
Ph.D. Biophysics Université Joseph Fourier, Grenoble 2004
Ph.D. Biophysics European Molecular Biology Laboratory, Heidelberg 2004
Post-doctoral Biophysics The Institut Laue Langevin, Grenoble 2006
Area(s) of Expertise
Neutron Diffraction