Area(s) of Expertise
Anemia induced by iron deficiency is one of the most prevalent nutritional disorders in the world. Most people obtain nutritional iron predominantly from plants. Our research focuses on understanding the molecular mechanisms that plants use to uptake, transport, and utilize iron, and respond to low iron conditions.
We use genomics, molecular biology, and genetics to identify root-specific transcriptional responses that regulate physiological alterations associated with iron deprivation in the model plant, Arabidopsis thaliana. Our work resulted in the first whole-genome, high-resolution transcriptional profile of iron deficiency in the root, and led to the identification of two regulatory genes that play a key role in how plants respond to low iron conditions.
Our continued efforts are focused on identifying additional iron deficiency response regulators and their corresponding gene targets, with the long-term goal of elucidating gene regulatory networks involved in plant iron homeostasis. Ultimately this information may lead to the generation of crops with increased nutritional content and increased yield when grown in poor soils.
- Plant Physiology (PB 421)
- A hybrid model connecting regulatory interactions with stem cell divisions in the root, Quantitative Plant Biology (2021)
- Solving the puzzle of Fe homeostasis by integrating molecular, mathematical, and societal models, Current Opinion in Plant Biology (2021)
- BioVision Tracker: A semi-automated image analysis software for spatiotemporal gene expression tracking in Arabidopsis thaliana, PLANT CELL BIOLOGY (2020)
- Computational solutions for modeling and controlling plant response to abiotic stresses: a review with focus on iron deficiency, Current Opinion in Plant Biology (2020)
- Iron homeostasis and plant immune responses: Recent insights and translational implications, Journal of Biological Chemistry (2020)
- MAGIC: Live imaging of cellular division in plant seedlings using lightsheet microscopy, PLANT CELL BIOLOGY (2020)
- Automated Imaging, Tracking, and Analytics Pipeline for Differentiating Environmental Effects on Root Meristematic Cell Division, Frontiers in Plant Science (2019)
- Dynamic modelling of the iron deficiency modulated transcriptome response in Arabidopsis thaliana roots, in silico Plants (2019)
- Hemerythrin E3 Ubiquitin Ligases as Negative Regulators of Iron Homeostasis in Plants, FRONTIERS IN PLANT SCIENCE (2019)
- Keep talking: crosstalk between iron and sulfur networks fine-tunes growth and development to promote survival under iron limitation, JOURNAL OF EXPERIMENTAL BOTANY (2019)
Ph.D., Molecular Genetics, University of Georgia (2005)
B.S., Biology, University of North Carolina, Chapel Hill (1998)