Arion Kennedy
Bio
Research Program Overview
Obesity remains an ongoing health issue in industrial societies and a major risk factor for metabolic diseases such as type 2 diabetes, fatty liver disease, and cardiovascular disease. Inflammation is a hallmark characteristic of these obesity-associated metabolic diseases. The Kennedy lab aims to determine the impact of the innate and adaptive immune system on obesity-associated metabolic disorders. Specifically, identification of antigens that drive T cell activation in obesity and nonalcoholic fatty liver disease. Furthermore, we are interested in understanding the impact that lipids and carbohydrates have on immune cell activation and function by investigating nutrient utilization, metabolic flux and molecular mechanisms.
Goodnight Early Career Innovator
Education
B.S. Chemistry Florida A&M University 2001
M.S. Chemistry Florida A&M University 2003
Ph.D. Nutrition University of North Carolina at Greensboro 2009
Post-Doctoral Immuno Metabolism Vanderbilt University 2014
Publications
- Data-dependent and -independent acquisition lipidomics analysis reveals the tissue-dependent effect of metformin on lipid metabolism , Metabolomics (2024)
- Fructose regulates the pentose phosphate pathway and induces an inflammatory and resolution phenotype in Kupffer cells , Scientific Reports (2024)
- Myeloid cell MHC I expression drives CD8+ T cell activation in nonalcoholic steatohepatitis , Frontiers in Immunology (2024)
- Regulation of Fructose Metabolism in Nonalcoholic Fatty Liver Disease , Biomolecules (2024)
- Prioritize biologically relevant ions for data-independent acquisition (BRI-DIA) in LC–MS/MS-based lipidomics analysis , Metabolomics (2022)
- Beneficial effects of eicosapentaenoic acid on the metabolic profile of obese female mice entails upregulation of HEPEs and increased abundance of enteric Akkermansia muciniphila , Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (2021)
- CD8+ T cells regulate liver injury in obesity-related nonalcoholic fatty liver disease , American Journal of Physiology-Gastrointestinal and Liver Physiology (2019)
- Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health , Diabetes (2019)
- High CD8 T-Cell Receptor Clonality and Altered CDR3 Properties Are Associated With Elevated Isolevuglandins in Adipose Tissue During Diet-Induced Obesity , Diabetes (2018)
- MFehi adipose tissue macrophages compensate for tissue iron perturbations in mice , American Journal of Physiology-Cell Physiology (2018)