Antibiotic resistance continues to pose a serious threat to human health; further of particular concern is the potential impact of agricultural practices on transmission of antibiotic resistance (genes and/or organisms) to humans through food production and consumption. Indeed, agricultural and environmental reservoirs serve as potential sources of antibiotic resistance genes of clinical significance. Research efforts focus on identifying agricultural, ecological, and waste management factors that impact the maintenance and dissemination of antibiotic resistance (genes and/or organisms) in soil.