{"id":179603,"date":"2020-07-28T09:54:31","date_gmt":"2020-07-28T13:54:31","guid":{"rendered":"https:\/\/cals.ncsu.edu\/news\/applying-insights-from-ecology-and-evolutionary-biology-to-the-management-of-cancer-an-interview-with-athena-aktipis\/"},"modified":"2024-08-24T03:21:45","modified_gmt":"2024-08-24T07:21:45","slug":"applying-insights-from-ecology-and-evolutionary-biology-to-the-management-of-cancer-an-interview-with-athena-aktipis","status":"publish","type":"post","link":"https:\/\/cals.ncsu.edu\/news\/applying-insights-from-ecology-and-evolutionary-biology-to-the-management-of-cancer-an-interview-with-athena-aktipis\/","title":{"rendered":"Applying Insights from Ecology and Evolutionary Biology to the Management of Cancer"},"content":{"rendered":"
AA:<\/b> Cancer cells evolve just like any population of individuals evolve. Tumors are made of cancer cells that have many different characteristics (some genetically based, some <\/span>epigenetically<\/b> based) and some of those cells survive and divide better than others do. This means that natural selection happens within tumors, favoring the cancer cells that are best at surviving and replicating.<\/span><\/p>\n AA: <\/b>All cancers, really. Cancer is fundamentally an evolutionary process, and so evolution can help us understand how tumors change over time and why some tumors are easier to treat than others.\u00a0<\/span><\/p>\n AA:<\/b> There are a lot of different ways for cancer cells to become resistant to chemotherapy. One big one is for them to <\/span>upregulate<\/b> what are called e-flux pumps. These are essentially little pumps on the outside of the cell that let them pump out toxins (like the chemicals used in chemotherapy) from inside the cell, making it easier for them to survive high doses of chemotherapy. Unfortunately the very process of treating a tumor often leads to selection for cells that are resistant to therapy, because cells without these mechanisms of resistance (like e-flux pumps) die, leaving only the resistant cells behind.\u00a0<\/span><\/p>\n AA: <\/b>Yes, exactly. The cancer cells that can survive therapy give rise to the next generation of cells in the tumor, and they pass along the genes that code for that resistance. But often resistance is also a matter of epigenetics – the gene expression state that the cell is in. And that epigenetic state can also get passed along when cells divide.\u00a0\u00a0<\/span><\/p>\n AA: <\/b>When we take this problem of the evolution of resistance really seriously, it can point us in the direction of new approaches to treatment. Some of the most exciting work going on in evolution and cancer is a new kind of therapy called \u2018<\/span>Adaptive Therapy<\/span><\/a>,\u2019 which aims to control the tumor rather than eradicate it. With this new approach, low doses of chemotherapy are used only when the tumor is growing, which doesn\u2019t select for resistance and makes it possible to keep using the same drug to treat the tumor for a very long time.\u00a0<\/span><\/p>\n AA: <\/b>The standard approach of high dose selects for resistance because it only leaves behind cells that can survive in the presence of the drug. By treating the tumor only when it is growing, adaptive therapy keeps the tumor under control without eliminating all the sensitive cells – sensitive cells are those cells that die in the presence of the chemotherapy. Keeping sensitive cells around is the key to making it possible to keep the tumor under control in the long term. When you aren\u2019t applying therapy the tumor grows, but generally the sensitive cells grow faster than the resistant cells (because resistance is usually metabolically costly for cells so it slows them down). So as long as there are sensitive cells around, treatment can keep working for a long time.That\u2019s the basic principle behind adaptive therapy.<\/span><\/p>\n AA:<\/b> Metastasis<\/b> is one of the biggest mysteries in cancer biology. There is no gene responsible for it, no molecular pathway to target; it is really hard to figure out why metastasis happens in the first place. Evolution and ecology can help, though.\u00a0<\/span><\/p>\n AA:<\/b> Well, we know, for example, that in many species that when they begin to use up their resources they often disperse. This is the same in a tumor where the high metabolism of cancer cells leads them to deplete the local resources around them, favoring <\/span>cells that can move<\/span><\/a>, invade and look for more resources. Cooperation among cancer cells also probably helps them to <\/span>survive the challenging process of metastasizing<\/span><\/a>. I think this is one of the most exciting areas of work in cancer biology, because if we can figure out how cancer cells are cooperating during metastasis, we can try to interfere with that cooperation to prevent or treat metastatic cancer.<\/span><\/p>\n AA:<\/strong> All multicellular organisms are susceptible to cancer, because <\/span>cells in our body can evolve to cheat<\/span><\/a> – to take advantage of the cooperation that all of our cells are usually engaged in to make us viable. This means that our susceptibility to cancer is a fundamental part of being a multicellular life form. Cancer arises from the cells of our own body, but then it takes on new characteristics as it evolves. So it is something dangerous that comes from a mutated version of ourselves.\u00a0<\/span><\/p>\n AA: <\/b>Yes, cancer evolutionary biologists make phylogenetic trees that can show the <\/span>evolutionary history of cancer cells<\/span><\/a> in the body. By taking samples from different places in a tumor and then <\/span>sequencing<\/b> the genomes of many different cells, it is possible to reconstruct the overall \u2018family tree\u2019 of a tumor (and sometimes also the metastases).\u00a0<\/span><\/p>\n AA:<\/b>\u00a0<\/span><\/p>\n AA:<\/b> I think the mentality of the \u2018war on cancer\u2019 is a big barrier. If people think the only way to deal with cancer is to eradicate it, then they might not consider long-term co-existence as even an option.<\/span><\/p>\n AA: <\/b>Haha! I\u2019m not in the business of putting anybody out of business. But I do think it is important to consider the economic incentives for drug development and clinical trials so that, as a society, we can allocate resources to those treatments and approaches that are most likely to save lives and preserve quality of life for cancer patients. I\u2019m not convinced that the current systems we have really aligns those incentives.<\/span><\/p>\n AA: <\/b>Bob Gatenby at Moffitt Cancer Center in Florida has pioneered adaptive therapy (as well as a bunch of other really innovative approaches to cancer control that I review in my book, <\/span>The Cheating Cell<\/span><\/i><\/a>). He and his colleagues have been doing clinical trials with adaptive therapy for several years now and have been getting <\/span>very promising results<\/span><\/a>. We are going to be starting a clinical trial with adaptive therapy for breast cancer with ASU and Mayo in the near future as well.<\/span><\/p>\n AA: <\/b>I\u2019m part of a group at ASU called the <\/span>Arizona Cancer Evolution Center<\/span><\/a>, led by <\/span>Carlo Maley<\/span><\/a>. We collaborate with lots of different scientists and clinicians on our projects. For this project we\u2019re working with Don Northfelt at Mayo and <\/span>Karen Anderson<\/span><\/a> at ASU.<\/span><\/p>\n AA:<\/b> Not all wrong – sometimes high dose therapy works, like in certain childhood cancers. It is just not always the right approach because it can make a tumor harder to treat by selecting for resistant cells.<\/span><\/p>\n AA<\/b>: Great question! This is one of the really exciting areas for <\/span>empirical<\/b> work and modeling. There is some evidence for division of labor in tumors – like some cells seem to specialize in producing growth factors, while others specialize in protecting the tumor from the immune system. My colleagues and I have suggested that there might be a distinction between \u201cbreeder\u201d and \u201cworker\u201d cells like you bring up – and we created a model that shows that this kind of division of labor would explain why tumors <\/span>aren\u2019t composed completely of \u2018<\/span>cancer stem cells<\/b><\/a>\u2019 (i.e., cancer cells that can give rise to a new tumor).<\/span><\/p>\n AA<\/b>: Well, some therapies have focused on eliminating so-called \u2018cancer stem cells,\u2019 but it\u2019s not as easy as it seems because that means that researchers have to find characteristics of these replicating cells that they can target, and these therapies also exert selection pressures on the population of cells. So it\u2019s all quite literally a moving target.<\/span><\/p>\n AA: <\/b>Yes, but not if new \u2018queens\u2019 can pop up after you think you\u2019ve destroyed them all. And we don\u2019t know enough about the regulation of these \u2018cancer stem cells\u2019 to know exactly what these dynamics are. Basically, we don\u2019t know what\u2019s going on inside the tumor in terms of how these supposed \u2018cancer stem cells\u2019 arise, or even if they are really a thing. So it\u2019s hard to build therapy around the idea of them when we don\u2019t know how they work.<\/span><\/p>\n AA<\/b>: Most multicellular organisms have sophisticated immune systems that can recognize and respond to cancer cells. Our immune system is essentially constantly surveilling our bodies for evidence of rouge cells and targeting them for destruction if they are detected. Usually when a patient comes to the clinic with cancer, the tumor cells have already evolved to escape from the immune system, like prey evolve ways of hiding from their predators like camouflage.\u00a0<\/span><\/p>\n AA: <\/b>I don\u2019t know about the immune system subconsciously employing my ideas. I think it\u2019s probably the other way around – I think we can learn a lot from the way that our immune system keeps cancer under control, and apply that knowledge (whether subconsciously or not) to developing better ways of keeping cancer under control, like adaptive therapy and some of the new <\/span>immunotherapies<\/b> that are being developed now. Since the dawn of multicellularity, life has had to evolve to keep cancer under control, so we have a lot to learn from taking an evolutionary approach.<\/span><\/p>\n You can also watch Athena’s July 2nd fermentology mini-seminar, “Fermenting for the Zombie Apocalypse,” here<\/a>.<\/p><\/blockquote>\n This post was originally published<\/a> in Department of Applied Ecology.<\/em><\/p>","protected":false,"raw":"Athena Aktipis<\/a> is an Assistant Professor in the Psychology Department at Arizona State University, co-Director of the Human Generosity Project and Director of Human and Social Evolution and co-founder of the Center for Evolution and Cancer at the University of California, San Francisco. Athena\u2019s latest book, <\/span>The Cheating Cell: How Evolution Helps Us Understand and Treat Cancer<\/span><\/i><\/a>, goes back millions of years to examine the many ways that multicellular life-forms\u2014from sponges and cacti to dogs and elephants\u2014have evolved to keep \u201ccheating\u201d cancer cells under control. It then goes on to consider the ways in which we can improve the ways in which we treat and manage cancer based on evolutionary insights. <\/span>Rob Dunn<\/span><\/a> (<\/span>RRD<\/b>) sat down to interview Athena (<\/span>AA<\/b>) about cancer, her book, and the future.\u00a0<\/span><\/p>\n
RRD: <\/b>In ordinary evolutionary biology, two key components are genetic variation and selection. Different organisms of a species differ in their genes. Selection favors some sets of genes relative to others. Do all cancers have genetic variation? Do all cancer cells have to deal with selection?<\/span><\/h3>\n
RRD:<\/b> Which kinds of cancers are most useful to think about from an evolutionary perspective?<\/span><\/h3>\n
RRD:<\/b> What sorts of things tend to favor cancer cells that are resistant to chemotherapy? What are the big factors?<\/span><\/h3>\n
RRD: <\/b>So in these cases chemotherapy inadvertently favors the subset of cells able to spit the chemotherapy drugs back out. They are the ones left and they then beget the next generation that, because it has the same genes, is also able to spit the drugs out? Is that more or less right?<\/span><\/h3>\n
RRD: <\/b>But sorry, you were saying\u2026\u00a0<\/span><\/h3>\n
RRD: <\/b>Why does only using the chemotherapy when the tumor is growing prevent resistance from evolving?<\/span><\/h3>\n
RRD:<\/b> What sorts of things tend to favor cancers that are metastatic and spread through the body?<\/span><\/h3>\n
RRD: <\/b>How?<\/span><\/h3>\n
RRD: <\/b>Do you think of cancers as being part of the body or as something foreign to it?<\/span><\/h3>\n
RRD: <\/b>Can you trace the evolutionary history of cancer cells in a body? A sort of biblical who begat who within a person?<\/span><\/h3>\n
RRD: <\/b>What are the steps, whether it is three or seven or however many, to managing cancer while taking evolutionary theory into account?<\/span><\/h3>\n
\n
RRD: <\/b>What is the biggest barrier to managing cancer that way?<\/span><\/h3>\n
RRD:<\/b> Are you going to put the companies that sell chemotherapy drugs out of business?<\/span><\/h3>\n
RRD: <\/b>That was a very political answer. Who is the closest to using these approaches clinically? Which doctors or hospitals should people be paying attention to?<\/span><\/h3>\n
RRD: <\/b>Who is \u201cwe\u201d in this case?<\/span><\/h3>\n
RRD: <\/b>Have we gotten cancer treatment all wrong in the past, or just partially wrong?<\/span><\/h3>\n
RRD: <\/b>Do cancer cells have division of labor like an ant colony? Are there \u201cbreeder\u201d cells and \u201cworker cells?\u201d<\/span><\/h3>\n
RRD: <\/b>How does this play into treatment?<\/span><\/h3>\n
RRD:<\/b> In theory though, if you could knock out the queens you could destroy the colony (to make the analogy to ant colonies). More or less?\u00a0<\/span><\/h3>\n
RRD: <\/b>Do the immune systems of some species have the ability to deal with cancer cells so as to slow their evolution?\u00a0<\/span><\/h3>\n
RRD: <\/b>Are they subconsciously employing some of your ideas?\u00a0<\/span><\/h3>\n
<\/h4>\n
Glossary:<\/h4>\n
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Athena Aktipis<\/a> is an Assistant Professor in the Psychology Department at Arizona State University, co-Director of the Human Generosity Project and Director of Human and Social Evolution and co-founder of the Center for Evolution and Cancer at the University of California, San Francisco. Athena\u2019s latest book, <\/span>The Cheating Cell: How Evolution Helps Us Understand and Treat Cancer<\/span><\/i><\/a>, goes back millions of years to examine the many ways that multicellular life-forms\u2014from sponges and cacti to dogs and elephants\u2014have evolved to keep \u201ccheating\u201d cancer cells under control. It then goes on to consider the ways in which we can improve the ways in which we treat and manage cancer based on evolutionary insights. <\/span>Rob Dunn<\/span><\/a> (<\/span>RRD<\/b>) sat down to interview Athena (<\/span>AA<\/b>) about cancer, her book, and the future.\u00a0<\/span>\r\n