{"id":5759,"date":"2022-09-13T14:11:36","date_gmt":"2022-09-13T18:11:36","guid":{"rendered":"https:\/\/cals.ncsu.edu\/psi\/people\/rbarran\/"},"modified":"2022-10-18T13:31:07","modified_gmt":"2022-10-18T17:31:07","slug":"rbarran","status":"publish","type":"person","link":"https:\/\/cals.ncsu.edu\/psi\/people\/rbarran\/","title":{"rendered":"Rodolphe Barrangou"},"content":{"rendered":"

Our laboratory focuses on the biology and genetics of CRISPR-Cas immune systems in bacteria. Using microbiology, molecular biology and genomics approaches, we investigate the use of CRISPR-Cas systems for three types of applications:<\/p>\n

    \n
  1. The exploitation of CRISPR spacer hypervariability for genotyping and phylogenetic studies of beneficial and pathogenic bacteria<\/li>\n
  2. Leveraging CRISPR-mediated interference for building up phage resistance in probiotic strains and starter cultures used in food manufacturing<\/li>\n
  3. Harnessing of Cas9-mediated, re-programmable dsDNA cleavage for genome editing in bacteria<\/li>\n<\/ol>\n

    These activities provide insights into the genetic and molecular processes that drive CRISPR-mediated adaptive immunity in bacteria and generate novel tools for the manipulation of industrially relevant organisms for food and biotechnological applications.<\/p>\n

    Teaching Activities<\/h3>\n
      \n
    • Introduction to Biopharmaceutical Sciences (BBS 201)<\/li>\n
    • MR Supervised Research (FS 693)<\/li>\n
    • Fermentation Microbiology (FS 725)<\/li>\n
    • DR Supervised Research (FS 893)<\/li>\n<\/ul>\n","protected":false},"author":828,"featured_media":5761,"template":"","meta":{"_acf_changed":false,"source":"","ncst_custom_author":"","ncst_show_custom_author":false,"ncst_dynamicHeaderBlockName":"","ncst_dynamicHeaderData":"","ncst_content_audit_freq":"","ncst_content_audit_date":"","_links_to":"","_links_to_target":""},"group":[111,136,141,145],"person_tag":[],"class_list":["post-5759","person","type-person","status-publish","has-post-thumbnail","hentry","group-faculty","group-genomics","group-molecular-biology","group-plant-breeding"],"acf":[],"_links":{"self":[{"href":"https:\/\/cals.ncsu.edu\/psi\/wp-json\/wp\/v2\/person\/5759","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cals.ncsu.edu\/psi\/wp-json\/wp\/v2\/person"}],"about":[{"href":"https:\/\/cals.ncsu.edu\/psi\/wp-json\/wp\/v2\/types\/person"}],"author":[{"embeddable":true,"href":"https:\/\/cals.ncsu.edu\/psi\/wp-json\/wp\/v2\/users\/828"}],"version-history":[{"count":5,"href":"https:\/\/cals.ncsu.edu\/psi\/wp-json\/wp\/v2\/person\/5759\/revisions"}],"predecessor-version":[{"id":6044,"href":"https:\/\/cals.ncsu.edu\/psi\/wp-json\/wp\/v2\/person\/5759\/revisions\/6044"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cals.ncsu.edu\/psi\/wp-json\/wp\/v2\/media\/5761"}],"wp:attachment":[{"href":"https:\/\/cals.ncsu.edu\/psi\/wp-json\/wp\/v2\/media?parent=5759"}],"wp:term":[{"taxonomy":"group","embeddable":true,"href":"https:\/\/cals.ncsu.edu\/psi\/wp-json\/wp\/v2\/group?post=5759"},{"taxonomy":"person_tag","embeddable":true,"href":"https:\/\/cals.ncsu.edu\/psi\/wp-json\/wp\/v2\/person_tag?post=5759"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}