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Zhe Lyu

Assistant Professor

4501 Thomas Hall


Research in the Lyu lab encompasses anaerobic and molecular microbiology, microbial
physiology and metabolism, and microbial ecology and evolution. We are particularly interested
in employing live microbes inclusive of both archaea and bacteria as model systems to broadly
study the functional roles of oxygen-sensitive microbes across multiple settings such as human
and animal health, agriculture, climate change, and biotechnology. To accomplish our research
goals, we aspire to 1) establish and integrate cultivation-dependent and -independent
approaches to define physiology-relevant microbial phenotypes at the community, population,
organismal or molecular levels; 2) develop and apply genetic, biochemical, and omic methods in
vitro and in vivo to mechanistically characterize the observed phenotypes; and 3) bring and
translate new findings into tangible solutions by harnessing the cross-boundary power of
Our current projects focus on:
– Microbiome and host health
– Methanogenic archaea and methanogenesis
– Archaea-bacterial interactions

View our current lab members here.

View All Publications on Google Scholar


Certificate Life Science Entrepreneurship Rice University 2019

Ph.D. Max Planck Institute Partner Group China Agricultural University 2012

B.S. School of Life Sciences Shandong University 2006

Area(s) of Expertise

Anaerobic microbiology, microbial physiology, archaea, methanogens, microbial interactions,
host-microbial interactions, translational microbiome