Deyu Xie
Professor
Gardner Hall 4210
Bio
The research interests in my laboratory focus on understanding the structure and biosynthesis of plant natural products. Currently, my lab is working on flavonoids, terpenes and alkaloids. We are using a combinatorial approach that includes phytochemistry, metabolomics, molecular biology and biochemistry to understand the structures and biogenesis of these compounds. Meanwhile, we are developing the three groups of metabolites as a platform to study the metabolic biology of plant natural products. We are applying our findings to establish metabolic engineering technology to produce novel natural products for pharmaceuticals or modify crop plants to synthesize natural products for biofuel. We are interested in establishing novel approaches to screen for anti-cancer, anti-malaria, anti-virus and anti-aging natural products.
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Education
Ph.D. Plant Physiology and Plant Molecular Biology Institute of Botany, Chinese Academy of Sciences 1997
M.S. Cytogenetics Beijing Normal University 1993
B.S. Biology Hunan Normal University 1988
Area(s) of Expertise
Phytochemistry, Metabolomics and Metabolic Engineering
Publications
- Metabolic engineering of the anthocyanin biosynthetic pathway in Artemisia annua and relation to the expression of the artemisinin biosynthetic pathway , PLANTA (2023)
- Molecular understanding of anthocyanin biosynthesis activated by PAP1 in engineered redArtemisia annuacells and regulation of 2, 4-dichlorophenoxyacetic acid , (2023)
- Unrelated to phenylalanine: Feeding studies provide new insight into salicylic acid biosynthesis , JOURNAL OF INTEGRATIVE PLANT BIOLOGY (2023)
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Flavonols and dihydroflavonols inhibit the main protease activity of SARS-CoV-2 and the replication of human coronavirus 229E
, VIROLOGY (2022) - A de novo regulation design shows an effectiveness in altering plant secondary metabolism , JOURNAL OF ADVANCED RESEARCH (2022)
- Alternative splicing of CsJAZ1 negatively regulates flavan-3-ol biosynthesis in tea plants , PLANT JOURNAL (2022)
- Anthocyanins from muscadine (Vitis rotundifolia) grape fruit , CURRENT PLANT BIOLOGY (2022)
- Insights into acylation mechanisms: co-expression of serine carboxypeptidase-like acyltransferases and their non-catalytic companion paralogs , PLANT JOURNAL (2022)
- Molecular and biochemical characterization of two 4-coumarate: CoA ligase genes in tea plant (Camellia sinensis) , PLANT MOLECULAR BIOLOGY (2022)
- Transcriptional and Metabolic Characterization of Feeding Ramie Growth Enhanced by a Combined Application of Gibberellin and Ethrel , INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Grants
Plant lectins are a large group of proteins that do not have catalytic activities. They are carbohydrate-binding proteins that bind sugar groups of proteins, peptides, polysaccharides, lipids, and other glycoconjugates. However, the production of lectins in plants are not high. Under this project, we propose to test different Escherichia coli and expression vectors to induce plant lectins, develop expression induction approaches for a high production, and then establish a combination of tag and affinity-column chromatography methods to isolate lectins.
Borlaug Fellowship Program for Turkey fellow to spend 12 weeks at NC State conducting research to weaken wheat phenylalanine ammonia-lyase gene promotor by homology directed repaid CRISPR-Cas9 technology to obtain more economical and effective biofuel production.
Using antibiotics in feed has become a global concern due to its contribution to the antibiotic resistance. Exploring the alternatives to antibiotics is necessary for human health and animal productive efficiency. Proanthocyanidins extracted from engineered novel plants and cells with biological and medicinal activities will be screened in this project.
Borlaug Fellowship Program for Sri Lanka fellow to spend 12 weeks at NC State conducting research to identify and characterize candidate resistance genes against blister blight disease in teac (Chinese sinensis).
The fellow will work on a topic entitled “Metabolomics of cacao†under the mentoring of Dr. Deyu Xie. Through this project, the fellow will learn extraction approaches of metabolites from cacao nuts and chocolate, HPLC-qTOF-MS/MS based metabolomics, structural annotation of metabolites, principal component analysis, and heatmap and hierarchy clustering analysis. The fellow will be instructed to read important literatures to understand the principle of metabolomics. In addition, the fellow will attend Xie’s weekly lab meeting and departmental seminars to gain additional opportunities to learn research progresses in other topics. By the end of this program, the fellow will master main metabolomics-based technology for characterization of functional metabolites in cacao nuts and will be able to develop research projects at their home university.