Anna Stepanova
Associate Professor
Faculty
Thomas Hall 2501A
Area(s) of Expertise
Unlike mobile animals, sessile plants spend their lives in a fixed place and, being unable to move away, have to endure and withstand harsh conditions of their environment. To cope with this challenge, plants have learned to adapt to their surroundings by modifying their metabolic activity, growth rates and patterns. Our earlier work has focused on the elucidation of the role of two key plant hormones, auxin and ethylene, in the phenotypic plasticity of root growth and has uncovered a previously unknown ethylene-mediated regulation of auxin biosynthesis. Adequate levels of auxin production, perception, signaling, and response were found to be required for the ethylene-triggered morphological changes. Current efforts of the lab continue to center around plant hormones, specifically the mechanisms of ethylene signal transduction, auxin biosynthesis, hormone pathways’ crosstalk, and translational regulation of hormone responses. We are employing a combination of classical and molecular genetics, cell biology, genomics, and synthetic biology in Arabidopsis and tomato to decipher the basic molecular mechanisms governing plant adaptation and phenotypic plasticity.
Publications
- Leveraging synthetic biology approaches in plant hormone research, Current Opinion in Plant Biology (2021)
- An Improved Recombineering Toolset for Plants, The Plant Cell (2020)
- Development of a relative quantification method for infrared matrix-assisted laser desorption electrospray ionization mass spectrometry imaging of Arabidopsis seedlings, RAPID COMMUNICATIONS IN MASS SPECTROMETRY (2020)
- Monitoring Ethylene in Plants: Genetically Encoded Reporters and Biosensors, Small Methods (2020)
- Structure–Function Analysis of Interallelic Complementation in ROOTY Transheterozygotes, Plant Physiology (2020)
- An improved plant toolset for high-throughput recombineering (2019)
- Epigenetic silencing of a multifunctional plant stress regulator, ELIFE (2019)
- From Ethylene-Auxin Interactions to Auxin Biosynthesis and Signal Integration, PLANT CELL (2019)
- RiboStreamR: a web application for quality control, analysis, and visualization of Ribo-seq data, BMC GENOMICS (2019)
- A mechanistic framework for auxin dependent Arabidopsis root hair elongation to low external phosphate, Nature Communications (2018)
Publications
Education
Ph.D., Biology, University of Pennsylvania (2001)
B.S., Biology, University of Nevada (1995)