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Dr. Allan Brown
Plants for Human Health Institute
North Carolina State University
North Carolina Research Campus
Suite 4229, 600 Laureate Way
Kannapolis, NC 28081
Office Phone: 704.250.5417
Website: Plants for Human Health Institute
- Ph.D., University of Illinois
- M.S., New Mexico State University
- B.S., University of Minnesota
Appointment: 100% Research
Development of molecular markers for traits of value in fruit and vegetable crops
Dr. Allan Brown wants to improve broccoli and, in the long-term, human health. He is identifying the compounds in broccoli that are associated with certain health benefits such as cancer prevention. Dr. Brown is developing broccoli lines that have higher levels of anti-carcinogenic compounds such as sulforaphane and Indole-3-carbinol than are found in currently available broccoli. These compounds are found almost exclusively in cole crops and have demonstrated ability to enhance the body’s defense systems. The broccoli lines that Dr. Brown is working on also contain higher levels of lutein, beta-carotene, tocopherols, calcium and other beneficial compounds to protect against cancer and other chronic diseases. Dr. Brown’s long-term goal is to produce a “super broccoli” that contains even higher levels of beneficial compounds.
Blueberry Genome Project: Dr. Brown also is leading a multi-institution consortium of scientists to create the first genomic draft sequence of the blueberry. He hopes to use this sequence to identify those genes that impact how the blueberry creates all of the attributes that make it delicious and nutritious. Blueberry and cranberry, for example, are closely related. The compounds that make blueberry “blue” and cranberry “red” may also protect against diabetes and macular degeneration, for example. Dr. Brown is interested in how specific genes differ and how they are regulated.
- Watch a slide show that explains the science behind the project.
Cabbage: Dr. Brown’s lab will evaluate an extensive collection of cabbage germplasm from the Asgrow Vegetable Seeds’ breeding program. The Asgrow collection, the last committed cabbage breeding program in the United States, was acquired by Monsanto, which has gifted the collection to N.C. State University. This material has been evaluated in California, Wisconsin, Florida, Texas, North Carolina, Georgia, New Jersey, Brazil and India. Dr. Brown will continue with evaluation and selection to develop varieties that meet the needs of growers in North Carolina and the Southeast.
- Watch a FOX Charlotte segment on Dr. Brown’s vegetable research
- Brown AF, Paterson AH, Li L (2012) Genomics and breeding in food crops. In: Benkeblia N (ed) OMICs technologies: tools for food science, CRC, Boca Raton, pp 141-162
Peer Reviewed Publications
- Brown AF, Yousef GG, Reid R, Chebrolu K, Thomas A, Jackson J, Jeffery E, Juvik JA (2015) Genetic analysis of glucosinolate variability in broccoli florets using genome-anchored molecular markers. Theor Appl Genet (accepted)
- Brown AF, Yousef GG, Chebrolu K, Byrd R, Everhart K, Thomas A, Reid R, Parkin I, Sharpe A, Oliver R, Guzman I, Jackson E (2014b) High-density single nucleotide polymorphism (SNP) array mapping in Brassica oleracea: identification of QTL associated with carotenoid variation in broccoli florets. Theor Appl Genet 127:2051-2064
- Bian Y, Ballington J, Raja A, Brouwer C, Reid R, Burke M, Wang X, Rowland L, Bassil N, Brown AF (2014) Patterns of simple sequence repeats in cultivated blueberries (Vaccinium section Cyanococcus spp.) and their use in revealing genetic diversity and population structure. Mol Breed 34:675-689
- Rowland LJ, Ogden EL, Bassil N, Buck EJ, McCallum S, Graham J, Brown AF (2014). Construction of a genetic linkage map of an interspecific diploid blueberry population and identification of QTL for chilling requirement and cold hardiness. Mol Breed 34: 2033-2048
- Wisniewski M, Nassuth A, Teuli`eres C, Marque C, Rowland J, Cao JB, Brown AF (2014) Genomics of Cold Hardiness in Woody Plants Crit Rev Plant Sci 33:92-124
- Yousef GG, Lila MA, Guzman I, Ballington JR, Brown AF (2014) Impact of interspecific introgression on anthocyanin profiles of southern highbush blueberry J. Amer Soc Hort Sci 139:1–14.
- Brown AF, Yousef GG, Guzman I, and Chebrolu KK, Werner DJ, and Parker M, Gasic K, Perkins-Veazie P (2014) Variation of carotenoids and polyphenolics in peach and implications on breeding for modified phytochemical profiles J Amer Soc Hort Sci 139:1–11. 2014.
- Gupta V, Estrada A, Blakley I, Reid R, Patel P, Meyer M, Uggerhoj S, Brown AF, Lila MA, and Loraine AE (2014) RNA-Seq analysis and annotation of a draft blueberry genome assembly identifies candidate genes involved in fruit ripening biosynthesis of bioactive compounds and stage-specific alternative splicing Giga Sci (accepted)
- Yousef GG, Grace MH, Guerrero-Medina JL, Neff S, Guzman I, Brown AF, Raskin I, and Lila MA (2014) Concentrating immunoprotective phytoactive compounds from fruits and vegetables into shelf-stable protein-rich ingredients. Plant Foods for Human Nutrition
- Yousef, G., Brown AF, Funakoshi Y, Mbeunkui F, Grace M, Ballington J, Loraine A, Lila M (2013). Efficient quantification of the health-relevant anthocyanin and phenolic acid profiles in commercial cultivars and breeding selections of blueberries (Vaccinium spp.). J Agric Food Chem 61: 4806–4815.
- Panthee, D., Brown AF, Yousef G, Ibrahem R, Anderson C (2013) Novel molecular marker associated with Tm2a gene conferring resistance to tomato mosaic virus in tomato. Plant Breed 132:413-416
- Panthee D, Perkins-Veazie P, Randall D, Brown AF (2013) Lycopene estimation in tomato lines using infrared absorbance and tomato analyzer. Int J Vegetable Sci 19:240-255
- Kwon S, Brown AF, Hu J, Mcgee R, Watt C, Kisha T, Timmerman-Vaughan G, Grusak M, Mcphee K, Coyne C (2012) Genetic diversity, population structure and genome-wide marker-trait association analysis of the USDA pea (Pisum sativum L.) core collection. Genes Genomics 34: 305-320.
- Brown AF, Jeffery EH, Juvik JA (2007) A PCR-based linkage map of broccoli and identification of quantitative trait loci associated with harvest date and head weight. J Amer Soc Hort Sci 132:507–513.
- Coyne CJ, Brown AF, Timmerman-Vaughan GM, McPhee KE, Grusak MA (2005) Refined USDA-ARS pea core collection based on 26 quantitative traits. Pisum Genetics 37:3-6
- Jeffery EH, Brown AF, Kurlich AC, Keck AS, Matusheski N, Klien BP, Juvik JA (2003) Variation in content of bioactive components in broccoli. J Food Compos Anal 16:323-330
- Brown AF, Yousef GG, Jeffery EH, Klein BP, Kushad MM, Wallig MA, Juvik JA Glucosinolate profiles in broccoli (Brassica oleracea L.): stability over environments and implications for cancer chemoprotection. J Amer Soc Hort Sci 127: 807-813
- Jeffery, EH, Brown AF, Klein BP, Wallig MA, Juvik JA (2002) Content variation in bioactive food components. Nutrition Today 37: 208-211
- Brown AF, Juvik JA, and J.K. Pataky. (2001) Quantitative trait loci in sweet corn associated with partial resistance to Stewart’s wilt, northern corn leaf blight and common rust. Phytopathology. 91:293-300
- Kushad MK, Brown AF, Kurlich AC, Juvik JA, Klein BP, Wallig MA, Jeffery EH (1999) Variation of glucosinolates in vegetable crops of Brassica oleracea J. Agric. Food Chem. 47:1541-1548.
- Kurlich AC, Tsau GJ, Brown AF, Klein BP, Jeffery EH, Kushad M, Wallig MA, Juvik JA (1999) Carotene, tocopherol, and ascorbate contents in subspecies of Brassica oleracea. J. Agric. Food Chem. 47:1576-1581.