Type: Emeritus Faculty
Education:
PhD, University of Kansas
Postdoctoral, University of Melbourne
Contact Info
Office: 2560 Thomas Hall, 919-515-7088
Lab: 2560 Thomas Hall, 919-515-5759
Fax: 919-515-3355
Email: Bill@Atchleylab.org
Website: Visit our Lab Home Page
Computational biology and molecular evolution
The major thrust of my research lies in computational biology and deals with broad questions in molecular evolution. I am particularly interested in modeling structure and evolution of transcriptional regulators, exploring the origin and evolution of regulatory gene networks, and the application of multivariate statistical methods to high dimensional molecular data.
Atchley WR, Zhao J, Fernandes A, and Drueke T. (2005). Solving the sequence "metric" problem. Proc Natl Acad Sci USA. 102: 6395–6400. [pdf Reprint]
Atchley WR, and Fernandes A. (2005). Sequence signatures and the probabilistic identification of proteins in the Myc-Max-Mad network. Proc Natl Acad Sci USA. 102: 6401–6406. [pdf Reprint]
Buck MJ, and Atchley WR. (2005). Networks of coevolving sites in structural and functional domains of serpin proteins. Mol Biol Evol. 22:1627–1634. [pdf Reprint]
Buck MJ, and Atchley WR. (2003). Phylogenetic analysis of plant basic helix-loop-helix proteins. J Mol Evol. 56: 742–750. [pdf Reprint]
Atchley WR, Lokot T, Wollenberg K, Dress A, and Ragg H. (2001). Phylogenetic analyses of amino acid variation in the serpin proteins. Mol Biol Evol. 18: 1502–11. [pdf Reprint ]
Ragg H, Lokot T, Kamp PB, Atchley WR, and Dress A. (2001). Vertebrate serpins: construction of a conflict-free phylogeny by combining exon-intron and diagnostic site analyses. Mol Biol Evol. 18: 577–84. [pdf Reprint ]
