Type: Associate Faculty
PhD, University of California, San Diego
Postdoctoral, The Salk Institute for Biological Studies
Postdoctoral, The Johns Hopkins University School of Medicine
Office: 3501 Thomas Hall
Website: Visit our Lab Home Page
Research in my laboratory focuses on three areas. Our major research effort is directed toward dissecting the genetic architecture of behavior in Drosophila melanogaster, including olfactory behavior, aggression and locomotion. Our second interest is to identify ensembles of genes that predispose to human disorders, including alcohol related phenotypes and ocular hypertension (a prelude to primary open angle glaucoma) through comparative genomic approaches by which we can identify evolutionarily conserved candidate genes and networks in Drosophila for follow-up association studies in human populations. A third long standing endeavor is aimed at determining the functions of the olfactomedin gene family in development of the nervous system, especially dendritic differentiation of olfactory sensory neurons, using conditional knock-out mice.
Wang P, Lyman RF, Mackay TFC, and Anholt RRH. (2010). Natural variation in odorant recognition among odorant binding proteins in Drosophila melanogaster. Genetics. 184: 745–758.
Ayroles JF, Carbone MA, Stone EA, Jordan KW, Lyman RF, Magwire MM, Rollmann SM, Duncan LH, Lawrence F, Anholt RRH, and Mackay TFC. (2009). Systems genetics of complex traits in Drosophila melanogaster. Nature Genetics. 41: 299–307.
Morozova TV, Ayroles JF, Jordan KW, Duncan LH, Carbone MA, Lyman RF, Stone EA, Govindaraju DR, Ellison CR, Mackay TFC, and Anholt RRH. (2009). Alcohol sensitivity in Drosophila: Translational potential of systems genetics. Genetics. 83: 733–745.
Zhou S, Stone EA, Mackay TFC, and Anholt RRH. (2009). Plasticity of the chemoreceptor repertoire in Drosophila melanogaster. PLoS Genet. 5: e1000681.
Yamamoto A, Zwarts L, Norga K, Callaerts P, Mackay TFC, and Anholt RRH. (2008). Neurogenetic networks for startle-induced locomotion in Drosophila. PNAS USA. 105: 12393–12398.